Motor Neurone Disease Genetics and Therapeutics Research at the Perron Institute, led by Professor Anthony Akkari, Professor of Pharmacogenetics at Murdoch University, aims to identify genetic mechanisms and mutations in neurological conditions, particularly motor neurone disease, with the aim of developing personalised treatments.
The research aims to develop effective drug therapies for MND that focus on genetic information known as Genomic Structural Variations (SVs). SVs can vary in length and location (within or around a gene), both of these variations may play a role in regulating how genes are expressed. Previous research has found different lengths of SVs are associated with diseases such as Alzheimer’s and MND.
A growing body of evidence is beginning to show that they are involved in many diseases and may be particularly important in neurodegenerative diseases such as MND.