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Parkinson’s Research

The objective of the Perron Institute’s Parkinson’s Research, led by Clinical Professor Soumya Ghosh, Professor Frank Mastaglia, Clinical Professor Michelle Byrnes and Dr Ryan Anderton, is to better understand Parkinson’s, the markers of disease progression and the causative factors to improve management and quality of life of people living with Parkinson’s.

Parkinson’s is a chronic neurodegenerative disease second only to Alzheimer’s disease in its global prevalence. Despite being widespread and affecting many individuals, very little is known about what factors cause Parkinson’s, with considerable variation in the age that symptoms commence, how rapidly it progresses and how people respond to treatment.

Research Focus

At present, very little is known about Parkinson’s and studies unveiling factors contributing to the disease, or biomarkers of the disease are necessary. The Parkinson’s Disease Research being conducted at the Perron Institute aims to:

  • Study how genes, treatments, the environment and clinical features influence the cause progression and course of Parkinson’s;
  • Identify early biomarkers of Parkinson’s, underlying risk factors influencing cognitive decline and impulse control disorders in Parkinson’s and study how the environment and gut microbiota influence the cause and progression of Parkinson’s;
  • Study patient demographics and possible underlying risk factors influencing the cognitive decline and/or development of impulse control disorders in Parkinson’s;
  • Create a bio-bank of Parkinson’s patient data and control data for future researchers and research methods.
  • Maintain the Parkinson’s Disease Registry.

Members

Parkinson’s nurse

Alexa Jefferson

PhD students

Megan Bakeberg

Jade Kenna

Ana Gorecki

Achievements

PUBLICATIONS

2019

Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson’s Disease. Megan C. Bakeberg, Alexa Jefferson, Maddeson Riley, Michelle Byrnes, Soumya Ghosh, Frank L. Mastaglia, Malcom K. Horne, Sarah McGregor, Rick Stell, Jade Kenna, Sue Walters, Dana Hince, and Ryan S. Anderton. Parkinson’s Disease, vol. 2019, Article ID 3124295, 8 pages, 2019. https://doi.org/10.1155/2019/3124295

2018

Maddeson Riley, Megan Bakeberg, Michelle Byrnes, Alexa Jefferson, Soumya Ghosh, Rick Stell, Frank L. Mastaglia, Dana Hince, and Ryan S. Anderton. Demographic and Clinical Predictors of Trait Impulsivity in Parkinson’s Disease Patients. Parkinson’s Disease 2018; DOI:10.1155/2018/9472120

GRANTS

Improvement of pulmonary function, gait and mobility in Parkinson’s disease following Inspiratory Muscle Training.

Ghosh, S., Cooper, I. 2018-2020: $140,500. Parkinson’s WA Zrinski Research Grant.

Investigating the influence of the gut microbiota in Parkinson’s disease.

Anderton RS, Mastaglia FL, Ghosh S, Koks S. 2018-2020: $108,338. Parkinson’s WA Zrinski Research Grant.