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The Perron Institute’s Neurotrauma Research includes Preventing Spreading Damage after Neurotrauma Research and Spinal Cord Repair Research.

Preventing Spreading Damage after Neurotrauma Research

The objective of Preventing Spreading Damage after Neurotrauma Research led by Professor Melinda (Lindy) Fitzgerald is focused around understanding and preventing the loss of function that occurs following neurotrauma. 

Professor Fitzgerald’s laboratory is co-located at the Perron Institute and Curtin University.

Research Focus

The Preventing Spreading Damage after Neurotrauma Research group assesses treatment strategies including nanotechnologies and combinatorial pharmacotherapeutics.

Their drive to translate their research findings to the clinic is evidenced by their current collaborative clinical trial assessing biomarkers and MRI for prediction of post-concussion syndrome.

Members

Professor Melinda (Lindy) Fitzgerald, Head, Neurotrauma Research Group

Mrs Carole Bartlett- MSc- Senior Research Assistant

Mr Terry McGonigle- BSc (Hons)- Laboratory Manager

Dr Yilin Mao- BSc (Hons), PhD- Postdoctoral Scientist  

Miss Sushmitha Raja- BSc, MSc- Research Assistant

Mr Marcus Giacci– BSc (Hons)- PhD candidate (3rd year)

Mrs Wissam Chiha- BSc (Hons)- PhD Candidate (2nd year)

Miss Aleksandra (Ola) Karolina Gozt- BSc (Hons)- PhD candidate (1st year)

Miss Lilly Toomey- BSc (Hons)- PhD candidate (1st year)

Miss Gopana Gopalasingam- BSc- Masters candidate (2nd year)

 

Mr Thomas Clarke- Undergraduate (exchange) student

Miss Anna Black- Undergraduate (exchange) student

 

M. Fitzgeralds Co-supervises:

Miss Priya Sarapnarajoonaidu – BSc, PhD candidate (2nd year)-

Miss Maimuna Majimbi- BSc, MSc, PhD candidate (1st year)

Achievements

GRANTS

PUBLICATIONS

2018

Journal Articles (Research)

  • Giacci, M.K., Bartlett, C.A., Smith, N.M., Iyer, K.S., Jiang, H., Guagliardo, P., Kilburn, M.R., and Fitzgerald, M. Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo. J Neurosci 38 (29): 6491-6504
  • Smith, N.M., Giacci, M.K., Gough, A., Bailey, C., McGonigle, T., Black, A.M.B, Clarke, T.O., Bartlett, C.A., Iyer, K.S., Dunlop, S.A., Fitzgerald, M. Inflammation and blood brain barrier breach remote from the primary injury following neurotrauma J Neuroinflammation 15(1): 201
  • *Giacci, M.K., Bartlett, C.A., Huynh, M., Kilburn, M.R., Dunlop, S.A. and Fitzgerald, M. (2018) Three dimensional electron microscopy reveals changing axonal and myelin morphology along normal and partially injured optic nerves. Scientific Reports 8:3979 doi:10.1038/s41598-018-22361-2
  • Naidu P.S.R., Norret M., Smith N.M., S.A. Dunlop, Taylor N.L., Fitzgerald M. and Iyer K.S. The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function. (2017). DOI: 10.1021/acs.langmuir.7b02568
  • *Chiha, W., LeVaillant, C.J., Bartlett, C.A., Hewitt, A.W., Melton, P., Fitzgerald, M., and Harvey, A.R. (2018) Retinal genes are differentially expressed in areas of primary versus secondary degeneration following partial optic nerve injury. PLOS ONE https://doi.org/10.1371/journal.pone.0192348

2017

Book Chapters (Research)

  • Eells, J. T., S. Gopalakrishnan, M. Salzman, K. Valter, J. Provis, R. Natoli, J. Mitrofanis, J. Stone, and M. Fitzgerald. 2017. “Low-Level Laser (Light) Therapy for the Treatment of Visual System Injury and Disease.” In Handbook of Low Level Laser Therapy Hamblin, M. R., M. de Sousa, and T. Agrawal., 435-452 Singapore: Taylor and Francis.

Journal Articles (Research)

  • Yates, N. J., M. K. Giacci, R. L. O Hare Doig, W. Chiha, B. E. Ashworth, J. Kenna, C. A. Bartlett, and M. Fitzgerald. 2017. “Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors.” Neural Regeneration Research 12 (2): 307-316.
  • Krishnan, V. S., Z. White, J. R. Terrill, S. I. Hodgetts, M. Fitzgerald, T. Shavlakadze, A. R. Harvey, and M. D. Grounds. 2017. “Resistance wheel exercise from mid-life has minimal effect on sciatic nerves from old mice in which sarcopenia was prevented.” Biogerontology 18 (5): 769-790.
  • Naidu, P. S. R., M. Norret, N. M. Smith, S. A. Dunlop, N. L. Taylor, M. Fitzgerald, and K. S. Iyer. 2017. “The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function.” Langmuir 33 (45): 12926-12933.
  • Krishnan, V. S., Z. White, J. R. Terrill, S. I. Hodgetts, M. Fitzgerald, T. Shavlakadze, A. R. Harvey, and M. Grounds.. “Impact of mid-life onset of resistance exercise on age-related morphological and molecular changes in sciatic nerves, associated with sarcopenia, in old male and female mice.” Experimental Gerentology xx Inpress.
  • Halstrom, A., E. MacDonald, C. Neil, G. Arendts, D. Fatovich, and M. Fitzgerald. 2017. “Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury.” Journal Of Clinical Neuroscience 35: 104-108.
  • Milbourn, H. R., and M. Fitzgerald. 2017. “Limiting oxidative stress following neurotrauma with a combination of ion channel inhibitors.”Discovery Medicine 23 (129)
  • Yates, N. J., S. Lydiard, B. Fehily, G. Weir, A. Chin, C. A. Bartlett, J. Alderson, and M. Fitzgerald. 2017. “Repeated mild traumatic brain injury in female rats increases lipid peroxidation in neurons.”Experimental Brain Research 235 (7): 2133-2149.
  • Fehily, B., and M. Fitzgerald. 2017. “Repeated mild traumatic brain injury: Potential mechanisms of damage.” Cell Transplantation 26 (7): 1131-1155.
  • O’Hare Doig, R. L., W. Chiha, M. K. Giacci, N. J. Yates, C. A. Bartlett, N. M. Smith, S. I. Hodgetts, A. R. Harvey, and M. Fitzgerald. 2017. “Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.” BMC Neuroscience18 (1)

Conference Articles (Research)

  • Fitzgerald, M., C. Bartlett, M. Kilburn, and M. Giacci. 2017. “Oxidative stress in differentiating oligodendroglia vulnerable to secondary degeneration following neurotrauma.” In 13th European Meeting on Glial Cells in Health and Disease, Jul 8, 2017, Edinburgh, SCOTLAND: WILEY.

2016

Journal Articles (Research)

  • O’Hare Doig, R. L., C. A. Bartlett, N. M. Smith, S. I. Hodgetts, S. A. Dunlop, L. Hool, and M. Fitzgerald. 2016. “Specific combinations of ion channel inhibitors reduce excessive Ca2+influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro.” Neuroscience 339: 450-462.
  • Clemons, T., M. Challenor, M. Fitzgerald, S. A. Dunlop, N. Smith, and K. S. Iyer. 2016. “Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes.” ACS Macro Lett. 5 (19): 1132-1136.
  • Lozić, I., R. V. Hartz, C. A. Bartlett,, J. A. Shaw, M. Archer, P. S. R. Naidu, N. M. Smith, S. A. Dunlop, K. Swaminathan Iyer, M. R. Kilburn, and M. Fitzgerald. 2016. “Characterization of Polymeric Nanoparticles for Treatment of Partial Injury to the Central Nervous System.” Data in Brief 7: 152-156.
  • Smith, N. M., D. Ho, A. M. Munshi, M. J. House, S. A. Dunlop, M. Fitzgerald, and K. Swaminathan Iyer. 2016. “Poly(glycidyl methacrylate) Coated Dual Mode Upconverting Nanoparticles For Neuronal Cell Imaging.” New J Chem 40: 6692-6696.
  • Hart, N. S., and M. Fitzgerald. 2016. “A new perspective on delivery of red-near-infrared light therapy for disorders of the brain.” Discovery Medicine 22: 147-156.
  • Lozic, I., R. V. Hartz, C. A. Bartlett, J. A. Shaw, M. Archer, P. S. R. Naidu, N. M. Smith, S. A. Dunlop, K. S. Iyer, M. R. Kilburn, and M. Fitzgerald. 2016. “Enabling dual cellular destinations of polymeric nanoparticles for treatment following partial injury to the central nervous system.” BIOMATERIALS 74: 200-216.
  • Krishnan, V. S., Z. White, C. D. McMahon, S. I. Hodgetts, M. Fitzgerald, T. Shavlakadze, A. R. Harvey, and M. D. Grounds. 2016. “A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice.” JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 75 (5): 464-478.
  • Smith, N. M., I. Gachulincova, D. Ho, C. Bailey, C. A. Bartlett, M. Norret, J. Murphy, A. Buckley, P. J. Rigby, M. J. House, T. S. Pierre, M. Fitzgerald, K. S. Iyer, and S. A. Dunlop. 2016. “An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles.” SCIENTIFIC REPORTS 6
  • Ashworth, B. E., E. Stephens, C. A. Bartlett, S. Serghiou, M. K. Giacci, A. Williams, N. S. Hart, and M. Fitzgerald. 2016. “Comparative assessment of phototherapy protocols for reduction of oxidative stress in partially transected spinal cord slices undergoing secondary degeneration.” BMC NEUROSCIENCE 17

2015

Journal Articles (Research)

  • Meloni, B. P., D. Milani, A. Edwards, R. Anderton, R. L. O’Hare Doig, M. Fitzgerald, N. T. Palmer, and N. W. Knuckey. 2015. “Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties.” Pharmacology and Therapeutics 153: 36-54.
  • O’Hare Doig, R. L., and M. Fitzgerald. 2015. “Novel combinations of ion channel inhibitors for treatment of neurotrauma.” Discovery Medicine 19 (102): 41-47.
  • Stephens, E. K., Y. Tauran, A. W. Coleman, and M. Fitzgerald. 2015. “Structural requirements for anti-oxidant activity of calix[n]arenes and their associated anti-bacterial activity.” CHEMICAL COMMUNICATIONS 51 (5): 851-854.
  • Challenor, M., R. O. Doig, P. Fuller, M. Giacci, C. Bartlett, C. H. Wale, G. S. Cozens, L. Hool, S. Dunlop, K. S. Iyer, J. Rodger, and M. Fitzgerald. 2015. “Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro.” BIOCHIMIE 112: 160-171.

Conference Articles (Research)

  • Giacci, M., C. Bartlett, N. Hart, and M. Fitzgerald. 2015. “Vulnerability and fate of oligodendroglia in areas of secondary degeneration following neurotrauma.” In 12th European Meeting on Glial Cell Function in Health and Disease, Jul 15, 2015, Bilbao, SPAIN: WILEY-BLACKWELL.
  • Giacci, M., C. Bartlett, N. Hart, and M. Fitzgerald. 2015. “Life, death, and oxidative stress: fate mapping oligodendrocyte progenitor cells following neurotrauma.” In 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Aug 23, 2015, Cairns, AUSTRALIA: WILEY-BLACKWELL.

2014

Journal Articles (Research)

  • O’Hare Doig, R. L., C. A. Bartlett, G. J. Maghzal, M. Lam, M. Archer, R. Stocker, and M. Fitzgerald. 2014. “Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration.” Exp Neurol 261: 136-146.
  • Fitzgerald, M. 2014. “Strategies to limit dysmyelination during secondary degeneration following neurotrauma.” Neural Regeneration Research 9 (11): 1096-1099.
  • Lozić, I., C. A. Bartlett, J. A. Shaw, K. Swaminathan Iyer, S. A. Dunlop, M. R. Kilburn, and M. Fitzgerald. 2014. “Direct quantification of Ca microdomain dynamics in specific cell types of white matter vulnerable to secondary degeneration, using NanoSIMS.” Metallomics6: 455-464.
  • Challenor, M., P. Gong, D. Lorenser, M. J. House, R. C. Woodward, T. S. Pierre, M. Fitzgerald, S. A. Dunlop, D. D. Sampson, and K. S. Iyer. 2014. “The influence of NaYF4:Yb,Er size/phase on the multimodality of co-encapsulated magnetic photon-upconverting polymeric nanoparticles.” DALTON TRANSACTIONS 43 (44): 16780-16787.
  • Lozic, I., C. A. Bartlett, J. A. Shaw, K. S. Iyer, S. A. Dunlop, M. R. Kilburn, and M. Fitzgerald. 2014. “Changes in subtypes of Ca microdomains following partial injury to the central nervous system.”METALLOMICS 6 (3): 455-464.
  • Giacci, M. K., L. Wheeler, S. Lovett, E. Dishington, B. Majda, C. A. Bartlett, E. Thornton, E. Harford-Wright, A. Leonard, R. Vink, A. R. Harvey, J. Provis, S. A. Dunlop, N. S. Hart, S. Hodgetts, R. Natoli, C. Van Den Heuvel, and M. Fitzgerald. 2014. “Differential effects of 670 and 830 nm red near infrared irradiation therapy: A comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury.” PLoS ONE 9 (8)

Conference Articles (Research)

  • Doig, R. L. O., D. L. Savigni, S. C. Payne, C. A. Bartlett, and M. Fitzgerald. 2014. “PROTECTING GLIA FROM OXIDATIVE STRESS DURING SECONDARY DEGENERATION FOLLOWING NEUROTRAUMA.” In 11th Symposium of the International-Neurotrauma-Society, Mar 19, 2014, Budapest, HUNGARY: MARY ANN LIEBERT, INC.

2013

Journal Articles (Research)

  • Savigni, D. L., R. L. O’Hare Doig, C. R. Szymanski, C. A. Bartlett, I. Lozić, N. M. Smith, and M. Fitzgerald. 2013. “Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma.” Neuropharmacology 75: 380-390.
  • Challenor, M., P. Gong, D. Lorenser, M. Fitzgerald, S. Dunlop, D. D. Sampson, and K. S. Iyer. 2013. “Iron Oxide-Induced Thermal Effects on Solid-State Upconversion Emissions in NaYF4:Yb,Er Nanocrystals.” ACS APPLIED MATERIALS & INTERFACES 5 (16): 7875-7880.
  • James, E., P. K. Eggers, A. R. Harvey, S. A. Dunlop, M. Fitzgerald, K. A. Stubbs, and C. L. Reston. 2013. “Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems.” ORGANIC & BIOMOLECULAR CHEMISTRY 11 (36): 6108-6112.
  • Cummins, N., C. A. Bartlett, M. Archer, E. Bartlett, J. M. Hemmi, A. R. Harvey, S. A. Dunlop, and M. Fitzgerald. 2013. “Changes to mitochondrial ultrastructure in optic nerve vulnerable to secondary degeneration in vivo are limited by irradiation at 670 nm.” BMC NEUROSCIENCE 14
  • Dev, S., J. Toster, S. V. Prasanna, M. Fitzgerald, K. S. Iyer, and C. L. Raston. 2013. “Suppressing regrowth of microfluidic generated drug nanocrystals using polyelectrolyte coatings.” RSC ADVANCES 3 (3): 695-698.
  • Payne, S. C., C. A. Bartlett, D. L. Savigni, A. R. Harvey, S. A. Dunlop, and M. Fitzgerald. 2013. “Early Proliferation Does Not Prevent the Loss of Oligodendrocyte Progenitor Cells during the Chronic Phase of Secondary Degeneration in a CNS White Matter Tract.” PLOS ONE 8 (6)
  • Clemons, T. D., M. Fitzgerald, S. A. Dunlop, A. R. Harvey, K. S. Iyer, and K. A. Stubbs. 2013. “An improved assay for the spectrophotometric determination of chondroitinase ABC activity.”NEW JOURNAL OF CHEMISTRY 37 (7): 1944-1949.
  • Szymanski, C. R., W. Chiha, N. Morellini, N. Cummins, C. A. Bartlett, R. L. O. Doig, D. L. Savigni, S. C. Payne, A. R. Harvey, S. A. Dunlop, and M. Fitzgerald. 2013. “Paranode Abnormalities and Oxidative Stress in Optic Nerve Vulnerable to Secondary Degeneration: Modulation by 670 nm Light Treatment.” PLOS ONE 8 (6)
  • Fitzgerald, M., S. Hodgetts, C. Van Den Heuvel, R. Natoli, N. S. Hart, K. Valter, A. R. Harvey, R. Vink, J. Provis, and S. A. Dunlop. 2013. “Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders.” Reviews In The Neurosciences 24 (2): 205-226.

Spinal Cord Repair Research

The objective of Spinal Cord Repair Laboratory Research led by Associate Professor Stuart Hodgetts is developing clinically relevant strategies for the treatment of spinal cord injury (SCI).

Professor Hodgett’s laboratory is co-located at the Perron Institute and The University of Western Australia.

Research Focus

A main focus is the use of multipotent, purified adult human mesenchymal precursor “stem cells” isolated from the bone marrow of SCI patients to promote endogenous repair in rodent models of SCI. Other strategies include gene therapy, neuroprotective peptides, tissue engineering (including self-assembling peptides, scaffolds), non-invasive therapies (including magnetic stimulation and infra-red/near infra-red light) and immunomodulation.

Members

Dr Sarah Lovett

Tylie Wiseman, Honours student

Professor Alan Harvey

Kalem Burnside, Honours student

Emmanuel Akinpelu, Honours student

Achievements

GRANTS

Current

NHMRC, Equipment

2017 Sampson, D., Pillow, J., Hool, L. Wyrwoll, C., Fitzgerald, M., Rodger, J., Hodgetts, S.I., Robinson, B., Yeoh, G., Ganss, R., Hamzah, j., Lee, G., Lansley, S., Endersby, R., Meloni, B. Increasing in-vivo physiological monitoring capability in UWA’s flagship preclinical 9.4 T MRI facility $49,694

Neurotrauma Research Program of Western Australia (NRP) Project

2017 Hodgetts S.I., Harvey AR, Wallace, V. Red/near infra-red irradiation therapy for spinal cord repair using implanted devices. $96,730

NRP, Project

2017 Grounds, M., Harvey AR, Hodgetts S.I., Krishnan, V.S. Benefits of exercise on age related changes in old spinal cords: implications for therapies to maintain and repair spinal cord function in elderly humans. $99,938

NRP, Project

2017 Meloni, B., Knuckey, N.K., Hodgetts, S. I., Cross, J. Pre-clinical assessment of poly-arginine peptide R180 as a therapeutic to reduce central nervous system injury following neurotrauma. $99,650

Total $4,462,311 since 2001.

PUBLICATIONS

1          Li, Ruohan, Harvey, A. R., Hodgetts, S. I., Fox, A. (2017). “Functional dissection of NEAT1 using genome editing reveals substantial localisation of the NEAT1_1 isoform outside paraspeckles”.  RNA. 2017 Jun;23(6):872-881 Impact Factor– 4.39

2          V. S. Krishnan, Z. White, J. Terrill, S. I. Hodgetts, M. Fitzgerald, T. Shavlakadze, A. R. Harvey & M. Grounds. (2017) “Resistance wheel exercise from mid-life has minimal effect on sciatic nerves from old mice in which sarcopenia was prevented”. Biogerontology 18(5) 769-790. Impact Factor– 3.231#

3          R. O’Hare Doig; W. Chiha; M. Giacci; N. Yates; C. Bartlett; N. Smith; S. Hodgetts; A. Harvey; M. Fitzgerald (2017) “Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma” BMC Neuroscience 2017 Aug 14;18(1):62  Impact Factor– 2.31#

4          R. L. O’Hare Doig, C. A. Bartlett, S.I. Hodgetts, S. A. Dunlop, L. Hool, M. Fitzgerald (2016).” Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro.” Neuroscience 339 p450-462. Impact Factor– 3.231 Citations: 1

5          Mangatt, M, Wong K, Anderson B, Epstein A, Hodgetts S.I., Leonard H, Downs J. (2016)  “Prevalence and onset of comorbidities in the CDKL5 disorder differ from Rett syndrome.” Orphanet Journal of Rare Diseases 11:39. Impact Factor– 3.3, Citations: 7

6          38) Vidya S. Krishnan, Chris McMahon, Stuart I. Hodgetts, Melinda Fitzgerald Miranda D. Grounds Alan R. Harvey, Tea Shavlakadze (2016). “A Neurogenic Perspective on Sarcopenia: time course study of sciatic nerves from aging mice” Journal of Neuropathology & Experimental Neurology 75 (5) p464-478. Impact Factor–4.38, Citations: 1

7          D. Moore, G. Ben-Ary, S. Hodgetts, A. Morris, N. Thompson, A. Fitch, D. Bakkum (2016). ‘CellF: The World’s First Neuron-Driven Synthesiser’. International Journal of Performing Arts and Digital Media, 12 (1):31-43 Citations:1

8          Sadwika, I.W., Feindel, K., Hodgetts, S.I., Bunt, S., Wittek, A., Miller, K. (2015). “MRI Protocols Comparison of In-Vivo Spinal Cord Imaging of the Rats for Segmentation Purposes”. International Journal of Research in Science Vol 1(3) Oct-Dec 2015, p1-4

9          Ho, D., Zou, J., Chen, X., Munshi, A., Smith, N.M. Agarwal, V., Hodgetts, S.I., Plant, G.W., Bakker, A., Harvey, A.R., Luzinov I., & Swaminathan Iyer, K. (2015). “Hierarchical patterning of multifunctional conducting polymer nanoparticles as a bionic platform for topographic contact guidance.”  ACS Nano. 9(2):1767-74 Impact Factor=12.03, Citations:10

10       Stuart I. Hodgetts, Michael Edel & Alan R. Harvey (2015) “The State of Play with iPSCs and Spinal Cord Injury Models”. J. Clin. Med. 4, 193-203. Invited Review, Citations: 5

11       Marcus Giacci, Nathan Hart, Richard V Hartz, Alan Harvey, Stuart Hodgetts, Melinda Fitzgerald (2015) “Method for the assessment of effects of a range of wavelengths and intensities of red/near-infrared light therapy on oxidative stress in vitro” JoVE. 97:e52221:1-8. Impact Factor–1.325, Citations: 1

12       *Alan R. Harvey, Sarah J. Lovett, Bernadette T. Majda, Jun H. Yoon, Lachlan P.G. Wheeler, Stuart I. Hodgetts “Neurotrophic factors for spinal cord repair: which, where, how and when to apply, and for what period of time?” (2015) Brain Research 1619: 36-71 Invited Review. Impact Factor=2.83, Citations: 26

13       Hodgetts, S. (2015) “Syncitium in Motion: Exploring Movement in the Skeletal Muscle Cell Shared by Scientific and Artistic Nuclei” Leonardo, Vol. Special Edition (“Agency in Motion”) LEONARDO, Vol. 48, No. 3, pp. 272–273 (ranked # 1 in its field)., Citations:

14       Stuart Hodgetts; Kelda Stagg; Marian Sturm; Michael Edel; Pilar Blancafort. (2014). “Long Live the Stem Cell: The Use of Stem Cells Isolated from Post Mortem Tissues for Translational Strategies” International Journal of Biochemistry & Cell Biology.  56:74–81 Invited Review Impact Factor=4.24, Citations: 6

15       Marcus Giacci, Lachlan Wheeler, Sarah Lovett, Emma Dishington, Bernadette Majda, Carole Bartlett, Emma Thornton, Elizabeth Harford-Wright, Anna Leonard, Robert Vink, Alan Harvey, Jan Provis, Sarah Dunlop, Nathan Hart, Stuart Hodgetts, Riccardo Natoli, Corinna Van Den Heuvel, Melinda Fitzgerald.  (2014). “Differential effects of 670 and 830nm red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury” PLOS ONE – August 2014, Volume 9 (8) e104565. Impact Factor=3.53, Citations: 18

16       Hodgetts, S. I. SCI-Fi, or a New Hope? (September 2013).  Medical Forum WA.  Invited commentary, Citations:

17       Godinho MJ, Teh L, Pollett MA, Goodman D, Hodgetts SI, Sweetman I, Walters M, Verhaagen J, Plant GW, Harvey AR. (2013) “Immunohistochemical, Ultrastructural and Functional Analysis of Axonal Regeneration through Peripheral Nerve Grafts Containing Schwann Cells Expressing BDNF, CNTF or NT3” PLoS One. Aug 9;8(8):e69987. Impact Factor=3.53, Citations: 27

18       S. Hodgetts, Simmons, P.J. and Plant G.W. (2013) “A comparison of the behavioral and anatomical outcomes in sub-acute and chronic spinal cord injury models following treatment with human mesenchymal precursor cell transplantation and recombinant decorin”. Experimental Neurology 248 (2013) p343–359 Impact Factor=4.65, Citations: 11

19       Ho, Dominic; Peerzade, Saquib; Becker, Thomas; Hodgetts, Stuart; Harvey, Alan; Plant, Giles; Woodward, Robert; Luzinov, Igor; St Pierre, Timothy; Iyer, K. (2013) ” Magnetic field directed fabrication of conducting polymer nanowires” Journal of the American Chemical Society 49(64):7138-40 Impact Factor=10.68, Citations: 6

20       Fitzgerald, Melinda; Hodgetts, Stuart; Van Den Heuvel, Corinna; Natoli, Riccardo; Hart, Nathan; Valter, Krisztina; Harvey, Alan; Vink, Robert; Provis, Jan; Dunlop, Sarah (2013) “Red/near-infrared light therapy for treatment of central nervous system injuries and disorders” Reviews in Neurosciences ;24(2):205-26. Impact Factor=3.31, Citations: 24

21       Alecia-Jane Twigger, Stuart Hodgetts, Luis Filgueira, Peter E. Hartmann, Foteini Hassiotou.  (2013) “From Breastmilk to Brains: The Potential of Stem Cells in Human Milk”.  Journal of Human Lactation 29(2):136-9. Impact Factor=1.98, Citations: 26

22       *Kramer, A.S., Harvey, A.R., Plant, G.W. and Hodgetts, S.I. (2013). “Systematic Review of Induced Pluripotent Stem Cell Technology as a Potential Clinical Therapy for Spinal Cord Injury”. Cell Transplantation (Special Edition) Vol. 22, pp. 571–617 Impact Factor=3.6, Citations: 17

23       S. Hodgetts, P.J. Simmons, G.W. Plant (2013). “Human Mesenchymal Precursor Cells (Stro-1+) from Spinal Cord Injury Patients Improve Functional Recovery and Tissue Sparing in an Acute Spinal Cord Injury Rat Model”. Cell Transplantation 22(3):393-412 Impact Factor=3.6, Citations: 23

24       Duff, T., Muhling, J., Godinho, M.G., Hodgetts, S.I. (2011). “How to Make Viral Tattoos” Leonardo 44 (2): 164–165 (#1 in field) Citations:3

25       Plant, Giles; Lee, Seok Voon; Hodgetts, Stuart; et al. (2007) “Myelin protein expression by olfactory ensheathing glia in vitro: a comparison to Schwann cells” Neuron Glia Biology 2 Suppl 1; S92-S92 , Citations: 0

26       Cui, Q*., Hodgetts, SI*, Y. Hu, J-M Luo, Harvey, A. (2007).  “Strain Specific Differences in the effects of Cyclosporin A and FK506 on the survival and regeneration of axotimised retinal ganglion cells in adult rats.”  Neuroscience 146: 986-999. Note: * – Co-1st Author Impact Factor=3.46, Citations: 26

27       Hodgetts, S., Radley H, Davies M, Grounds MD (2006).  “Reduced necrosis of dystrophic muscle by depletion of host neutrophils, or blocking TNFalpha function with Etanercept in mdx mice.”  Neuromuscular Disorders 16:p591-602. Impact Factor=3.13, Citations: 170

28       Miranda D. Grounds, Marilyn Davies, Jo Torrisi, Jason White, Stuart Hodgetts (2005).  “Silencing TNFa activity using Remicade® or Enbrel® blocks inflammation in whole muscle grafts: an in vivo bioassay to assess the efficacy of anti-cytokine drugs in mice.”  Cell and Tissue Research 320 (3):509-15.  Impact Factor= 3.68, Citations: 51

29       Bosio, E. Pullen, T.F., Fragall, C.T. Beilharz, M.W., Bennett, A.L., Grounds, M.D. Hodgetts, S.I., and Sammels, L. (2004). “A comparison between real-time quantitative PCR and DNA hybridisation for quantitation of male DNA following myoblast transplantation”. Cell Transplantation. 13(7-8):817-821.  Impact Factor=3.6, Citations: 9

30       Hodgetts,S.I. and Grounds, M.D. (2003).  “Irradiation of dystrophic host tissue prior to Myoblast Transfer Therapy enhances initial (not long-term) survival of donor myoblasts.” Journal Cell Science 116: p4131-4146. Impact Factor=6.0, Citations:21

31       Hodgetts,S.I. Spencer, M. and Grounds, M.D. (2003) “A Role for Natural Killer Cells in the Rapid Death of Cultured Donor Myoblasts After Transplantation ” Transplantation 75: p863-871.  Impact Factor= 3.54, Citations: 28

32       Sammels, L., C. Fragall, C., Hodgetts, S.I., Grounds, M.D. and Beilharz, M. (2002).  “Myoblast Transfer Therapy (MTT): Survival of Donor Male Myoblasts in Host Mice Depleted of Granulocytes”.  Neurological Sciences 199, Supp 1 P-044 Impact Factor=1.49, Citations:

33       Sammels, L., C. Fragall, C., Hodgetts, S.I., Grounds, M.D. and Beilharz, M. (2002).  “Myoblast transfer therapy (MTT): CFSE Labelling of Donor Myoblasts to Track Their Fate in Recipient Mdx Mice”. Neurological Sciences 199, Supp 1 P-043  Impact Factor=1.49, Citations:

34       Stuart I. Hodgetts, and Miranda D. Grounds. (2001). “Natural Killer Cells and the Death of Donor Myoblasts in Myoblast Transfer Therapy.”  Cell Transplantation 10 (6) p512.  Impact Factor=3.6, Citations:

35       Smythe GM, Hodgetts SI, Grounds MD. (2001). INVITED REVIEW: “Problems and Solutions in Myoblast Transfer Therapy”.  Journal of Cellular and Molecular Medicine 5(1): 33-47.  Impact Factor=5.9, Citations: 79

36       Stuart I Hodgetts and Miranda D Grounds. (2001) “Complement and myoblast transfer therapy: Donor myoblast survival is enhanced following depletion of host complement C3 using cobra venom factor, but not in the absence of C5”.  Immunology and Cell Biology 79 (3): 231-239.  Impact Factor=4.21, Citations:17

37       Smythe GM, Hodgetts SI, Grounds MD. (2000). “Immunobiology and the Future of Myoblast Transfer Therapy”. Molecular Therapy. 1(4): 304 -313.  Impact Factor=6.83, Citations: 78

38       Hodgetts, S.I., Beilharz, M.W., Scalzo, A.A. and Grounds, M.D.  (2000). “Why Do Cultured Transplanted Myoblasts Die In Vitro?  DNA Quantification Shows Enhanced Survival of Donor Male Myoblasts in Host Mice Depleted of CD4+ and CD8+ or NK1.1+ Cells.”  Cell Transplantation 9(4): 489-502. Impact Factor=3.6, Citations: 137

39       Urosevic, N., Silvia, O., Sangster, M.Y., Mansfield, J.P., Hodgetts, S.I., Shellam, G.R.  (1999). “Development and Characterisation of New Flavivirus-resistant Mouse Strains Bearing Flvr-like and Flvmr Alleles from Wild or Wild-derived Animals.”  Journal of General Virology 80: 897-906. Impact Factor= 3.13, Citations: 32

40       Hodgetts, S.I., Davies, M., Smythe, G.M., Fan, Y., Beilharz, M.W. and Grounds, M.D. (1998). “Quantitation of Donor Male Myoblast Survival in Cell Transplantation Experiments in Dystrophic Mice.” Muscle & Nerve Supp. 7 S126 Impact Factor=2.31, Citations:

41       Lancaster, M.U., Hodgetts, S.I., Mackenzie, J.S. and Urosevic, N. (1997). “Characterisation of Viral Defective RNA Produced During Persistent Infection of Vero Cells with Murray Valley Encephalitis Virus.” Journal of Virology 72(3): 2474-82. Impact Factor=4.85, Citations:54

42       Hodgetts, S.I., Buchanan, K.L., Byrnes, J. & Webb, C.F. (1995). “Differential Interaction of Nuclear Matrix Proteins with Regulatory Sequences Upstream of Immunoglobulin Heavy Chain Promoters.” Journal of Cellular Biochemistry Suppl 19D. Impact Factor=3.37, Citations:

43       Buchanan, K.L., Hodgetts, S.I., Byrnes, J. and Webb, C.F.  (1995).  “Differential Transcription Efficiency of Two Ig VH Promoters In Vitro.”  Journal of Immunology 155: 4270-4277. Impact Factor=5.36, Citations:18

(* Note: Review contains original data from my laboratory)  (#Denotes 5 year impact factor)

BOOK CHAPTERS

1) Hodgetts, S. & Harvey, A. R. (2016). “Neurotrophins in Spinal Cord Repair” in “NEUROTROPHINS”, Vitamins and Hormones, Academic Press/Elsevier – Invited Chapter. Chapter 15 p405-458 (In Press, October 2016) (SH 85%),

2) Sakiyama-Elbert, S.E., Johnson, P.J., Hodgetts, S. Plant, G.W. and Harvey, A.R. (2012).  Handbook of Clinical Neurology -, Vol. 109 (3rd series) Volume on Spinal Cord Trauma. Chapter 36:  “Artificial scaffolds to promote spinal cord regeneration” J. Verhaagen and J.W. McDonald III, Editors (SH 25%) Chapter 36, p575,

3) Hodgetts, S.I. , Plant G.W. and Harvery A.R.  Chapter 14. (2008)  “Spinal Cord Injury: Experimental Animal Models and Relation to Human Therapy”.  In  “The Spinal Cord” by Watson, C., Paxinos, G., Kayalioglu, G. and Heise, C.  Academic Press,. ISBN-10: 0123742471.  ISBN-13: 978-0123742476 (SH 50%).