Research shaping
the future of
neuroscience

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Specialist clinics
improving
quality of life

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The Perron Institute’s specialist clinics not only provide diagnosis, management and treatment for patients with complex neurological and neuromuscular diseases but they are involved in clinical research and clinical trials.

Clinical Trials

Clinical trials at the Perron Institute that are both pharmaceutical sponsored and investigator driven provide an opportunity for participation by some of our clinic patients. The Perron Institute consultants participating in clinical research and trials include Professors William Carroll, Allan Kermode, Soumya Ghosh and Frank Mastaglia, and Doctors Jason Burton and Merrilee Needham.

Motor Neurone Disease (MND) trials

Recruiting for Fortitude MND / ALS trial

This study aims to assess the effect of a drug (CK-2127107) versus placebo on muscle function and global function in motor neurone disease / ALS.

FORTITUDE ALS (MND) Trial

Functional Outcomes in a Randomized Trial of Investigational Treatment with CK-2127107 to Understand Decline in End Points – in ALS

This study aims to assess the effect of a drug (CK-2127107) versus placebo on muscle function and global function.

Assessments during the trial will measure respiratory function, disease progression through speech production and fine motor characteristics, quality of life and muscle strength.

We will also measure how well the drug is tolerated through blood tests and reported side effects.

We are now recruiting for this trial and are interested in hearing from people who:

  • Were diagnosed with MND (ALS) within the last 2 years,
  • Are able to swallow tablets, are not currently using any form of non-invasive ventilation,and
  • Are able to commit to 12 weeks of study (approximately 8 visits to the Perron Institute in Nedlands).

Principle Investigator: Professor Merrilee Needham

Sub-investigators: Dr Rajini Rajanayagam, Dr Robert Edis

Co-ordinator: Sue Walters

Research personnel: Jo Borrelli & Shaila Jeereddy

Should you have any questions about this study, please contact:

Jo Borrelli (MND Clinical Trials Research Assistant)

joanne.borrelli@perron.uwa.edu .au

Phone: (08) 6457 0200

Perron Institute

Ground Floor, RR Block, QE II Medical Centre
8 Verdun Street, Nedlands,
Western Australia 6009

MS balance trial

Recruiting for MS balance trial

The Centre for Restorative Neurology at the Perron Institute is currently recruiting for a clinical trial to improve walking and balance in patients with Relapsing Remitting and Progressive Multiple Sclerosis by combining balance training and non-invasive brain stimulation.

Centre for Restorative Neurology

Clinical trial in the use of newer modalities of treatment in the rehabilitation of MS patients.

Enhancing balance and gait in patients with Multiple Sclerosis – combined use of balance training with non-invasive brain stimulation.

This is a collaborative project between the Centre for Restorative Neurology, Sir Charles Gairdner Hospital and Multiple Sclerosis WA, and is supported by MS Research Australia.

This study aims to evaluate whether brain stimulation (transcranial direct current stimulation – tDCS) added to a structured balance treatment program improves gait and balance, translating to increased mobility and independence in patients with MS.

We are looking to recruit people who are able to walk independently and have mild to moderate balance impairment. This intervention will be in addition to their regular outpatient therapy program prescribed by their physicians. All patients will participate in 2 weekly sessions of structured balance therapy for 6 weeks (12 sessions, each about 2 hours). Half of the group will receive the brain stimulation and half will receive the sham stimulation. To date there have been no adverse effects associated with tDCS.

Principal Investigator: Clinical Professor Soumya Ghosh, Director, Centre for Restorative Neurology

Co-investigators: Gary Thickbroom, Alec Ring, Michelle Byrnes, Ian Cooper, Jennifer Eisenhauer, David Hathorn, Emily Brough, Frank Mastaglia, Sue Walters, William Carroll, Allan Kermode and Jason Burton.

Should you have questions about the study please contact:

Prof. Soumya Ghosh / Sue Walters
at the Perron Institute clinic, phone (08) 6457 0200.

Centre for Restorative Neurology, the Perron Institute, QEII Medical Centre, 4th Floor, A Block Floor, Nedlands, WA 6009.

Phone: (08) 6457 0200 and Fax: (08) 6457 0281.

Stroke robotics trial

Recruiting for Stroke robotics trial

The Perron Institute’s Centre for Restorative Neurology is currently recruiting first ever ischemic stroke patients to enhancing recovery of function after stroke with a combined use of physical training (robot-assisted arm therapy) and non-invasive brain stimulation.

Centre for Restorative Neurology

Clinical trial in the use of newer modalities of treatment in the rehabilitation of stroke victims.

Enhancing recovery of function after stroke – combined use of physical training (robot-assisted arm therapy) with non-invasive brain stimulation.

This is a collaborative project between the Centre for Restorative Neurology, Sir Charles Gairdner Hospital, Royal Perth Rehabilitation Hospital (Shenton Park), Fremantle Hospital, and is supported by the Neurotrauma Research Program.

This study aims to evaluate whether brain stimulation (transcranial direct current stimulation – tDCS) added to a computer controlled exercise (robot-guided arm therapy) will provide added benefit in recovery of the upper limb following stroke.

We are looking to recruit people who have had a first ever ischemic stroke causing arm weakness. This intervention will be in addition to their regular outpatient therapy program prescribed by their rehabilitation physicians.

This study will recruit patients within the first 6-9 months following stroke, when they are discharged from inpatient care. All patients will participate in 2-3 weekly sessions of robotic arm therapy for 6-9 weeks (18 sessions, each about 2 hours). Half of the group will receive the brain stimulation and half will receive the sham stimulation. To date there have been no adverse effects associated with either robotic arm therapy or tDCS.

Principal Investigator: Clinical Professor Soumya Ghosh, Director, Centre for Restorative Neurology.

Co-investigators: Prof. Gary Thickbroom, Dave Hathorn, Emily Brough, Susan Walters, Jennifer Eisenhauer, Assoc. Prof. Ian Cooper, Prof. Frank Mastaglia, Dr. Michelle Byrnes, Prof. Graeme Hankey, Prof. David Blacker, Dr. Tony Alvaro, Dr. Andrew Kelly, Dr. Lay Kun Kho, Prof. Dylan Edwards.

Should you have questions about the study please contact:

Prof. Soumya Ghosh/ Susan Walters

at the Perron Institute clinic, phone (08) 6457 0200.

Centre for Restorative Neurology, the Perron Institute, QEII Medical Centre, 4th Floor, A Block Floor, Nedlands, WA 6009.

Phone: (08) 6457 0200 and Fax: (08) 6457 0281.