A major strategic goal of the Perron Institute is to provide student opportunities for young scientists. Many of our academic staff supervise postgraduate students for Masters by Research and PhD Degrees.
Each research project is tailor-made for the student after discussion with the relevant research group head.
The areas of research for potential students include:
The Perron Institute works closely with the following Universities in enrolling students:
One of the Perron Institute’s most important functions is training the neuroscientists of tomorrow through its innovative PhD program. Over the years, the Perron Institute has produced a succession of PhD graduates who have gone to occupy important positions in research organisations, universities and industry. Over the last four years, the Perron Institute has produced eight PhD graduates.
The Perron Institute is in the process of expanding its research now it has moved into the new Sarich Neuroscience Research Institute building in 2017. As part of this expansion, new student opportunities continue to emerge for PhD, Masters by Research and Honours students whose goal is to become members of the next generation of outstanding medical researchers focusing on neurological and neuromuscular disorders.
In partnership with universities across Perth, including the University of Western Australia, Murdoch University, Curtin University, Edith Cowan University and with links to Notre Dame University, the Perron Institute provides a supportive learning environment for students engaged in research studies.
As one of the world’s leading medical research institutes in the field of molecular therapies for neuromuscular disorders and with research strengths in stroke, multiple sclerosis, nucleic acid therapeutics, motor neurone disease and restorative neurology, the Perron Institute has an outstanding track record of translating findings from the research laboratory into outcomes that directly improve health care and quality of life.
The Perron Institute values its students for their contribution to new ideas and discoveries as well as to the life of the Institute as a whole.
We look forward to you joining us in our quest to combat the neurological disease through research. Please contact norman.palmer@perron.uwa.edu.au if you are a prospective PhD or Masters by Research and are interested in studying at the Perron Institute.
The Perron Institute is pleased to announce the next round of Byron Kakulas Prestige Scholarships open to students who commence their PhD in 2021 under the supervision of a Perron Institute researcher(s).
Named in honour of the Perron Institute’s Founding Director, Emeritus Professor Byron Kakulas AO, the Byron Kakulas Prestige Scholarships are to be awarded competitively based on academic merit to the most outstanding students who are planning to commence their PhD studies at the Perron Institute in 2021. To be eligible, students must:
Students are encouraged to apply for a Perron Institute Prestige Scholarship at the same time as they apply for an RTP, IPRS or other scholarship.
The scholarships will be awarded on the basis of academic record and research potential taking into account academic record, honours performance or equivalent, comments from two referees and, where relevant, publications.
The Byron Kakulas Perron Institute Prestige Scholarship will provide a top-up living allowance scholarship of $10,000 per year for the duration of the degree as well as $5,000 towards conference and other research-related travel.
Applications should include:
Contact norman.palmer@perron.uwa.edu.au for further information on how to apply.
Stroke
The Stroke Research group has demonstrated that poly-arginine and arginine-rich peptides have potent neuroprotective properties in in vitro injury models that mimic the effects of stroke (e.g. excitotoxicity), as well as in animal stroke models. Due to the effectiveness of these arginine-rich peptides following stroke, it is anticipated that this class of peptide will also possess neuroprotective actions in other acute and chronic neurological disorders such as global cerebral ischaemia, brain trauma (TBI), perinatal hypoxia-ischaemia, spinal cord injury (SCI), Alzheimer’s disease, and motor neuron disease.
Our primary focus is the application of arginine-rich peptides to limit CNS injury after stroke and other acute neurological disorders. In our stroke models we are investigating the effectiveness of the peptides to extend the therapeutic window and minimize reperfusion injury following re-canalisation therapy (e.g. tPA thrombolysis and thrombectomy). In addition, studies are underway or planned to assess the effectiveness of arginine-rich peptides in animal models of TBI, perinatal hypoxia-ischaemia, and SCI. We are also developing arginine-rich peptides that are resistant to proteolysis so that they are suitable for future oral administration to treat chronic neurodegenerative disorders and to improve recovery after acute CNS injuries.
Investigate the effectiveness of arginine-rich peptides to extend the therapeutic window and reduce reperfusion injury following re-canalisation in stroke
This project will perform peptide dose trials to investigate the effectiveness of arginine-rich peptides to extend the therapeutic window and minimise reperfusion injury following re-canalisation in stroke. The project will evaluate different peptides and administration routes (intravenous versus intra-arterial).
Assessment of peptides to improve recovery following CNS injury
In addition to reducing injury, there is evidence that arginine-rich peptides can improve recovery after acute brain and SCI injury. This project will investigate the effectiveness of arginine-rich peptides to improve recovery when administered several days after an acute brain injury. For example, three to five days following an acute CNS injury (stroke, TBI or SCI), peptides will be administered intraperitoneally for one to four weeks during which time animals will be assessed for functional improvement.
Investigate the stability, pharmacokinetics and effectiveness of modified arginine-rich peptides when administered orally in normal rats and in rats subjected to a stroke
This project will investigate the effectiveness of arginine-rich peptides to improve recovery when administered several days after an acute brain injury. For example, three to five days following an acute CNS injury (stroke, TBI or SCI), peptides will be administered intraperitoneally for one to four weeks during which time animals will be assessed for functional improvement.
Investigate the effectiveness of arginine-rich peptides to improve stroke outcomes in female rats, aged rats and in long-term functional studies
This project will perform peptide dose trials to investigate the neuroprotective effectiveness of arginine-rich peptides in female and aged rats subjected to stroke. In addition, ability of arginine-rich peptides to provide long-term functional and histological benefits will also be investigated.
Investigate the effectiveness of arginine-rich peptides to reduce injury and improve outcomes following SCI.
In addition to the potential to reduce injury following SCI, there is evidence that arginine-rich peptides can improve recovery. This project will perform peptide dose trials to investigate the effectiveness of arginine-rich peptides to reduce injury and to improve recovery after SCI.
Nucleic Acid Therapeutics
Nucleic Acid Therapeutics research focuses on theranostics, the science that brings together therapeutics and diagnostics (therapeutics and diagnostics = theranostics). Research in our laboratory is focused on developing novel personalised precision therapeutics and diagnostics using novel nucleic acid-based technologies targeting an array of human diseases, including neuromuscular diseases and solid cancers. To achieve this end, we utilise the applicability of novel functional nucleic acids (FNAs), such as nucleic acid aptamers and various other therapeutic nucleic acids including antisense oligonucleotide (AO), short interfering RNAs (siRNAs), DNAzymes and microRNA targeting oligonucleotides (anitmiRs). Specifically, we construct designer nucleic acid drug candidates by conjugating novel therapeutic nucleic acids that target the underlying molecular pathological hallmarks of the disease, with nucleic acid aptamers as a delivery cargo for tissue specific delivery to relevant disease-specific sites within the body to maximise efficacy and minimise toxicity and adverse side effects. For developing successful nucleic acid-based drugs, the use of chemically-modified nucleotides is essential in order to improve the pharmacokinetic properties. To this end, we routinely synthesise nucleic acid sequences with various chemical modification including locked nucleic acids nucleotides (LNA), 2’-O-Methyl RNA nucleotides (2’-OMe) and 2’-Fluoro RNA nucleotides (2’-F), using two state-of-the-art oligonucleotide synthesisers.
Molecular Therapies
The Molecular Therapies Laboratory based in the Centre for Comparative Genomics at Murdoch University has been at the forefront in the development of personalised treatments for serious inherited and acquired conditions. We are well positioned to become a pipeline for drug development by designing antisense oligonucleotides, genetic drugs capable of altering gene expression and bypassing disease-causing mutations.
The majority of human genes undergo “splicing” during gene expression, a process where exons are precisely joined together and non‐coding introns are removed. At least three quarters of our gene transcripts undergo alternative splicing, allowing an increased diversity of gene expression by using different exon combinations in a developmental or tissue-specific manner. We have shown it is possible to re-direct gene transcript processing, in essence “therapeutic alternative splicing” to treat human disease.
Our Duchenne muscular dystrophy program is the most advanced, with one compound, eteplirsen currently in Phase 2 and 3 clinical trials, and FDA approval is pending. Extended Phase 2 clinical trials evaluating eteplirsen have shown altered natural history of this devastating muscle wasting disease, and we are now exploring opportunities to treat other inherited and acquired conditions, in addition to neuromuscular diseases.
An estimated 25% of pathogenic nonsense and missense mutations have been found to alter pre‐mRNA splicing, and loss of exon recognition has been identified as a common mechanism of gene dysregulation. We believe that antisense oligonucleotide mediated alternative splicing can be developed to treat selected mutations causing many genetic disorders.
Research projects will study the processes of constitutive and alternative splicing, modifier genes and characterize disease‐causing gene lesions to develop appropriate antisense therapies for:
Restorative Neurology
At the Centre for Restorative Neurology, we study neural mechanisms of brain plasticity and recovery of function from brain injury. Our team has a diverse background involving neurology, physiotherapy, psychology and physics. We use non-invasive brain stimulation (Transcranial Magnetic Stimulation) to study pathophysiology of cerebral dysfunction in stroke, multiple sclerosis and Parkinson’s disease. In clinical trials, we investigate the use of new therapeutic options provided by non-invasive brain stimulation (Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation) in neurological disorders. Brain stimulation is combined with physical therapy to enhance neuroplasticity and motor learning. We use computerised robots for treatment and assessment, the MIT-Manus Inmotion Arm and Hand Robot for upper limb therapy and the Balance Master (computerised posturography) for analysing and improving balance and lower limb function.
Current research projects appropriate for PhD projects:
Clinical trials
Demyelinating Diseases
The Demyelinating Diseases Research Group is focused on characterisation of the clinical, laboratory, radiological and genetic aspects of multiple sclerosis (MS). Clinical measures in MS are imprecise and the disease proceeds over decades with immensely variable phenotype and progression.
The Perth MS cohort is a large longitudinal cohort of highly characterised patients, numbering over 1,600 cases and covering the entire spectrum of disease phenotypes. Our research is conducted within an ethical environment where patients with MS have received and continue to receive cutting edge high quality clinical management and intervention, with early access to evidence based therapies. Our service provision integrates closely with allied health specialists from various hospital agencies, teaching hospitals and the Multiple Sclerosis Society of Western Australia.
In addition to our own cutting edge clinical, radiological, genetic, epigenetic, serological and immunological studies in MS, we have been engaged in many collaborative ventures both in Australia and overseas that have been recognised in peer-reviewed publications. We are undertaking collaborative work with the genetic data from the IMSGC, ANZGENE and Wellcome Trust.
Over time our Group has been involved in a number of Clinical Drug Trials including JEMS, ESTEEM, EARLIMS, BEYOND, CORAL, STARS, SURPASS, RECORD, STRATIFY, TAPPS, INNATE, PrevANZ, The Linomide Study, PROGRESS, COPERNICUS, the Haematological Stem Cell Transplant Program for Refractory MS, and we have provided a Fingolimod Start Up Clinic at the the Perron Institute, which is free of charge to patients with MS.
Development of biomarkers for progressive MS based on clinical, radiological and laboratory measures of disease progression.
As a member of Progressive MS Alliance, we are engaged in development and assessment of putative biomarkers of progressive disease. The absence of an early, reliable indicator of progressive disease is a critical question. Two PhD projects will focus on developing biomarkers for progressive MS based on clinical, radiological and laboratory measures of disease progression. The study will sub-categorise progressive patients into those with and without clinical and/or MRI activity. This distinction between those with inflammatory activity and those without may prove to be of considerable importance, not only in choosing therapies, but also in determining whether there are multiple mechanistic pathways to progressive disease. The aim of two PhD proposals will be to determine the earliest, most reliable indicators of secondary progressive disease.